Shotgun Metagenomics
2 articles
Life Sciences
Who Is There, What Can They Do, or What Are They Doing? Choosing a Human Microbiome Analysis Method
Choosing the right human microbiome analysis method—16S rRNA sequencing, shotgun metagenomics, or metatranscriptomics—is crucial for obtaining meaningful biological insights, as each method answers a distinct question about community composition, potential, or activity.
Sofia Petrova·October 21, 2026
Human Origins
Shotgun vs. Targeted Capture: Choosing the Right Tool to Uncover Ancient Diseases
Scientists must choose between broad, untargeted shotgun metagenomics for discovering unknown ancient pathogens and sensitive, targeted DNA capture for screening known agents. This decision depends on the research question, sample quality, and cost, balancing discovery versus focused screening.
Dr. Elena Ortiz·October 7, 2026